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Longevity
Metformin
Live Longer, Function Better
Important safety information: Metformin can rarely cause lactic acidosis, with higher risk in kidney or liver impairment or alcohol abuse. Not recommended with an eGFR under 30 mL/min. See full safety information
- 3-month supply
- Oral medication
- Fast, free shipping
- 100% online, confidential consultations
- US board-certified doctors, trusted medications
- Free rushed delivery from the pharmacy
Not sure? Find your plan Medication facts
HighPoint Rx does not manufacture compounded medications. Actual product appearance and labeling of the medication you receive may differ from website images.
- Confidential online consultation
- Board-certified Physicians, trusted medications
- Fast, free shipping
- GLP-1 for weight loss support
About this treatment
Metformin
Metformin is a well-known oral medication traditionally used to manage type 2 diabetes. In recent years, it has gained recognition in longevity and anti-aging medicine due to its impact on insulin sensitivity, mitochondrial health, inflammation, and cellular aging. As a caloric restriction mimetic, Metformin is now widely used off-label to support metabolic health, fat loss, and cellular resilience, with potential to reduce age-related diseases and improve health span.
Benefits:
- Enhances insulin sensitivity and stabilizes blood sugar
- May reduce visceral fat and improve body composition
- Supports mitochondrial function and metabolic flexibility
- May reduce the risk of age-related diseases (heart disease, cancer, cognitive decline)
- Activates cellular repair pathways (AMPK, autophagy)
What to expect
How metformin is usually started.
From our patient FAQ. Your provider sets your exact schedule.
- Start
500mg once daily
Taken with food to reduce stomach side effects.
- Then
Increased gradually
Up to 1000 to 2000mg daily, if tolerated.
- Ongoing
Consistent, long-term use
Best combined with low-glycemic nutrition and exercise. Check vitamin B12 once a year.
Medication facts
What to know before you start.
Condensed from our patient FAQ. Your provider's directions and your prescription label always come first.
Rx onlyMetformin
- Medication
- Metformin, an oral medication
- Supply
- 3-month supply
- Typical start
- 500mg once daily, gradually titrated up to 1000 to 2000mg daily if tolerated
- How to take
- With food, to reduce stomach side effects
- Missed a dose
- Skip it and resume at the next scheduled time. Do not double up.
- Monitoring
- Check vitamin B12 once a year with long-term use
Medications only issued when clinically appropriate after provider evaluation.
Three steps, all online
How does it work?
No appointments, no travel, skip pharmacy lines.
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Step 1: Take the health questionnaire
100% online and confidential health intake form
Respond to a brief set of medical questions.
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Step 2: A provider reviews your visit
Based on your state, a synchronous online visit may be required
You'll hear back from one of our US-based doctors in 24 hours.
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Step 3: Get your meds
Fast free delivery from our accredited pharmacies
Rush No-Contact delivery, so no signature is required.
Healthcare on your terms.
No appointments, no travel, skip pharmacy lines. Receive a physician-led consultation and prescription approval from the comfort of your home.
Get Started
Illustrative imageQuestions
Frequently Asked Questions
Everything you need to know about services and platform.
Support hours 9:00am – 6:00pm, Monday to Sunday.
What can I expect with Metformin treatment?
• Start with 500mg once daily, gradually titrate up to 1000–2000mg daily if tolerated
• Week 1–2: Improved blood sugar and appetite control
• Week 4+: Enhanced energy, fat loss, cognitive clarity
• Full anti-aging and metabolic benefits seen with consistent, long-term use
• Best when combined with fasting, low-glycemic nutrition, and exercise
• Missed dose? Skip and resume at the next scheduled time—do not double up
What are the possible side effects of Metformin?
Common (Typically transient):
• Nausea
• Diarrhea
• Gas or bloating
• Metallic taste
Less Common / Monitor If Present:
• Vitamin B12 deficiency (check annually)
• Lactic acidosis (rare; risk higher in kidney/liver impairment or alcohol abuse)
• Decreased appetite or mild fatigue
Precautions:
- Not recommended in patients with eGFR <30 mL/min
- Caution with alcohol or severe calorie restriction
- Monitor B12 annually with long-term use
- Take with food to reduce GI side effects
Important safety information
- Metformin can rarely cause lactic acidosis, with higher risk in kidney or liver impairment or alcohol abuse. Not recommended with an eGFR under 30 mL/min.
- Use caution with alcohol or severe calorie restriction.
- Less common: vitamin B12 deficiency, decreased appetite or mild fatigue. Check vitamin B12 once a year with long-term use.
- Common and typically short-lived: nausea, diarrhea, gas or bloating, and a metallic taste.
This is not a complete list. Talk with your provider about your health history and any other medications. In case of an emergency, please call 9-1-1.
Tell your provider about any side effects. You can also report side effects of prescription drugs to the FDA at fda.gov/medwatch or 1-800-FDA-1088.